Hi Perspx, I managed to get MSHelp working on the Vista Machine. I reinstalled Visual Studio 2005 SDK on the machine and everything worked like charm. However this is very surprising that there has been no articles or any help anywhere on the web for the same. Perspx I appreciate your help and thank you very much for sharing your opinions. Hope this will help others in getting similar issues resolved :) Vinay ComponentOne LLC. www.componentone.com