You will probably have to turn on SSL (secure sockets layer) to get access to server. Turn on the EnableSsl property of your SmtpClient object. You may also have to select another port to send on. Talk to whoever is administering the smtp server, or read any documentation for this smtp server. If you already can send mail through this server, from another program (outlook, or windows mail, or whatever), lookup the connection parameters in that program. Here is full example of mail client that uses SSL: http://www.codeproject.com/Articles/66257/Sending-Mails-in-NET-Framework.aspx[^]