I have 2 seperate boxes each with 4Gb RAM running Vista and they work well (as well as Vista can work I suppose :). Although sometimes 32 bit apps can run quicker under WOW64 environment, sometimes not, you still have added benefit of more system RAM in your box, which is always a good thing. That RAM is used for other things besides just VS, so it keeps the rest of the system running nicer. FYI - I haven't had any trouble with drivers apart from a really old Logitech camera (like 8 years old) which I didn't expect to work anyway. I was anticipating lots more pain in the driver department, but it's actually been really good.