Similar to others, but with extra partitions: C: SSD with OS and apps Data on mirrored HDDs, partitioned as: D: Data; includes "My Documents" (location moved) and data like Quicken, spreadsheets, dev stuff, etc. E: Download; legacy, but I've kept it. Drivers, software updates, useful apps M: Media; My Pictures/Music/Videos. Largest of the partitions, naturally Backup for D: is twice/day (incremental), D/E/M each week. Use both external USB and NAS (with mirrored 2TB drives). Replace the HDDs at least every 3 years. As for organization of folders, definitely a personal preference, BUT I tend to organize with major folders such that location + file name generate meaning. Example: file named "Minutes 1-1-16" in subfolder "Team Meetings" in folder "Dev Project X". Sometimes OCD works to your advantage.