Our shop has a good many applications setup this way. You need to make sure the correct version of the framework is installed on each client. Also, if you decide to use Crystal Reports in the application, there are merge modules that need to be installed on the client's machine. I believe VS 2005 addresses this problem, but we were using 2003 at the time. As Dave already mentioned, security is a big factor. You have to adjust the trusts on the client's machine to execute an application on the server. We used a MSDN support call on the security issue and below are the links he gave us. Maybe this info can help with the security issues. Because of some of these issues our shop is looking into clickonce deployment in VS 2005 to be a better solution for us in the future. We just installed VS 2005 this week so we're just starting to figure out the new features. Good luck! :) SAMPLES No-Touch deployment - http://msdn.microsoft.com/library/default.asp?url=/library/en-us/dv\_vstechart/html/vbtchNo-TouchDeploymentInNETFramework.asp .NET Security Samples - http://msdn.microsoft.com/library/default.asp?url=/library/en-us/dnvssamp/html/vbcs\_RoleBasedSecurity.asp MODIFYING SECURITY URL Security Zones: http://msdn.microsoft.com/library/default.asp?url=/workshop/security/szone/urlzones.asp Configuring Permission Sets Using the .NET Framework Configuration Tool - http://msdn.microsoft.com/library/default.asp?url=/library/en-us/cpguide/html/cpconusingnetconfigurationtooltoworkwithpermissionsets.asp Project Folder Not Secure Dialog Box - http://msdn.microsoft.com/library/default.asp?url=/library/en-us/vsintro7/html/vxurfprojectfoldernotsecuredialogbox.asp Performing Common Security Policy Tasks Using the .NET Framework Configuration Tool - http://msdn.microsoft.com/library/default.asp?url=/library/en-us/cpguide/html/cpconperformingcommonsecuritypolicytasksusingnetframeworkconfigurationtool.asp Deploying Security Policy - http://msdn.microsoft.com/library/default.asp?url=/library/en-us/cpguide/html/cpcondeployingsecuritypolicy.asp DEFINITIONS Security Permssions - http://msdn.microsoft.com/library/default.asp?url=/library/en-us/cpref/html/frlrfsystemsecuritypermissions.asp Name Permission Sets - http://msdn.microsoft.com/library/default.asp?url=/library/en-us/cpguide/html/cpconnamedpermissionsets.asp (This has the definition for "Local Intranet", as I mentioned before this should be every computer within the domain) Security Zones: - http://msdn.microsoft.com/library/default.asp?url=/wo