You can achive through Dropdown on click Javascript event. Based on the selected value function EnableValidator() { if(document.getElementById('<%=ddlCmethod.ClientID%>').value=='Telephone') { ValidatorEnable(document.getElementById('<%=valmanEmail.ClientID%>'), false); ValidatorEnable(document.getElementById('<%=valmanPhone.ClientID%>'), true); } else { ValidatorEnable(document.getElementById('<%=valmanEmail.ClientID%>'), true); ValidatorEnable(document.getElementById('<%=valmanPhone.ClientID%>'), false); } } Just call 'EnableValidator()' function on click of the dropdownlist This will work.
Shanmugam R