You can consider using the following technologies on Mac: 1) Silverlight 4 as a replacement for WPF (the most closest approximation though not 100% complete) 2) SQLite as a replacement for SQL CE (Mono has good support for SQLite) 3) In this case, you will need to re-design your app to support multiple layers (DAL/BLL exposed via WCF - it is partially supported by Mono, specifically for Mac), UI layer running on Silverlight. This is what I would do if I were in your shoes.