Dont worry, guys, I already worked it out myself. here is the solutionif anyone come across the same issue next time: basically once the target column be pointed, then the fco applys on that sepcific cell when condition meets: GridEXFormatCondition fco = new GridEXFormatCondition( this.gridEX1.RootTable.Columns[4], ConditionOperator.Equal, true); fco.TargetColumn = this.gridEX1.RootTable.Columns[4]; fco.FormatStyle.BackColor = Color.LightYellow;