Oooh, I can add to this one. Last week a regular overnight MS update went wild and caused my VS2010 to crash at its splash screen, even in safe mode. Event Viewer said it was an internal .net problem, with clr.dll. Not good. So I rolled those updates back, rebooted, and was okay. A coworker of mine was not so lucky. The updates caused her Windows 7 to BSOD at *its* splash screen, repeatedly. Had to ship it back to tech support for reinstallation of the whole thing. Since the whole interbun was not alight with similar complaints, we think it was caused by the particular whole-disk encryption that my company uses. But still... seems really sloppy.
Jason